Beneath the surface: Amino acid variation underlying two decades of dengue virus antigenic dynamics in Bangkok, Thailand
Angkana T. Huang; Henrik Salje; Ana Coello Escoto; Nayeem Chowdhury; Christian Chávez; Bernardo García‐Carreras; Wiriya Rutvisuttinunt; Irina Maljkovic Berry · 2022 · PLoS Pathogens
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Neutralizing antibodies are important correlates of protection against dengue. Yet, determinants of variation in neutralization across strains within the four dengue virus serotypes (DENV1-4) is imperfectly understood. Studies focus on structural DENV proteins, especially the envelope (E), the primary target of anti-DENV antibodies. Although changes in immune recognition (antigenicity) are often attributed to variation in epitope residues, viral processes influencing conformation and epitope accessibility also affect neutralizability, suggesting possible modulating roles of nonstructural prote
Abstract by Angkana T. Huang; Henrik Salje; Ana Coello Escoto; Nayeem Chowdhury; Christian Chávez; Bernardo García‐Carreras; Wiriya Rutvisuttinunt; Irina Maljkovic Berry, PLoS Pathogens (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.ppat.1010500