Negative / Null Result ReportOpen accessMedicine· cited by 23

Effect of Concurrent Chemoradiation With Celecoxib vs Concurrent Chemoradiation Alone on Survival Among Patients With Non–Small Cell Lung Cancer With and Without Cyclooxygenase 2 Genetic Variants

Nan Bi; Jun Liang; Zongmei Zhou; Dongfu Chen; Zhixue Fu; Xu Yang; Qinfu Feng; Zhouguang Hui · 2019 · JAMA Network Open

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Importance: Treatment of locally advanced non-small cell lung cancer (NSCLC) remains challenging. The rationale of combining a cyclooxygenase 2 (COX-2) inhibitor with concurrent chemoradiation (CCRT) was based on results of preclinical research and prospective clinical studies; however, no randomized clinical trial has provided evidence of a direct comparison with CCRT alone. Objective: To determine the effect of combined selective COX-2 inhibition with standard CCRT on survival among patients with unresectable stage III NSCLC. Design, Setting, and Participants: A single-center, open-label, ra

Abstract by Nan Bi; Jun Liang; Zongmei Zhou; Dongfu Chen; Zhixue Fu; Xu Yang; Qinfu Feng; Zhouguang Hui, JAMA Network Open (2019) — licensed CC BY 4.0.

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