The role of microglia in multiple sclerosis: implications for treatment with Bruton’s tyrosine kinase inhibitors
Patrick Vermersch; Laura Airas; Thomas Berger; Florian Deisenhammer; Nikolaos Grigoriadis; Hans‐Peter Hartung; Melinda Magyari; Veronica Popescu · 2025 · Frontiers in Immunology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background: Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), characterized by inflammation and neurodegeneration. The pathophysiology of MS, especially its progressive forms, involves various cellular components, including microglia, the primary resident immune cells of the CNS. This review discusses the role of microglia in neuroinflammation, tissue repair, and neural homeostasis, as well as their involvement in MS and explores potential therapeutic strategies targeting microglial function. Methods: A literature search conducted in August 202
Abstract by Patrick Vermersch; Laura Airas; Thomas Berger; Florian Deisenhammer; Nikolaos Grigoriadis; Hans‐Peter Hartung; Melinda Magyari; Veronica Popescu, Frontiers in Immunology (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fimmu.2025.1495529