Associations between the C-reactive protein-triglyceride glucose index and the incidence and progression trajectory of cardiometabolic multimorbidity: a multi-state model study
Lei Yuan; Zhe Zhao; Hongxiang Peng; Wen Hong Zong; Juanfang Zhu; Huilong Qu; Chun Liang; Jan Nilsson · 2026 · Cardiovascular Diabetology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: The C-reactive protein-triglyceride-glucose index (CTI) has been proposed as a novel biomarker for insulin resistance and inflammation. However, its role in the progression trajectory of cardiometabolic multimorbidity (CMM) remains unclear. We aimed to investigate the involvement of the CTI in the CMM progression trajectory. METHODS: This prospective study included 266,049 individuals from the UK Biobank, who were free of cardiometabolic diseases (CMD) at baseline. CMM was defined as the presence of two or more CMDs, including type 2 diabetes (T2D), coronary heart disease (CHD), an
Abstract by Lei Yuan; Zhe Zhao; Hongxiang Peng; Wen Hong Zong; Juanfang Zhu; Huilong Qu; Chun Liang; Jan Nilsson, Cardiovascular Diabetology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12933-026-03174-4