LAG-3 expression in the inflammatory microenvironment of glioma
Maximilian J. Mair; Barbara Kiesel; Katharina Feldmann; Georg Widhalm; Karin Dieckmann; Adelheid Wöhrer; Leonhard Müllauer; Matthias Preusser · 2021 · Journal of Neuro-Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
PURPOSE: Immune modulatory therapies including immune checkpoint inhibitors have so far failed to result in clinically meaningful efficacy in glioma. We aimed to investigate lymphocyte activation gene 3 (LAG-3), an inhibitory receptor on immune cells and target of second-generation immune checkpoint inhibitors, in glioma. METHODS: 97 patients with diffuse glioma (68 with glioblastoma, 29 with WHO grade II-III glioma) were identified from the Neuro-Biobank of the Medical University of Vienna. LAG-3 expression in the inflammatory microenvironment was assessed by immunohistochemistry (monoclonal
Abstract by Maximilian J. Mair; Barbara Kiesel; Katharina Feldmann; Georg Widhalm; Karin Dieckmann; Adelheid Wöhrer; Leonhard Müllauer; Matthias Preusser, Journal of Neuro-Oncology (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1007/s11060-021-03721-x