BRAF inhibition-associated nuclear remodeling is linked to cancer-associated fibroblast activation.
Wang J; Soley BDS; Xiao Y; Siegfried LG; Zhou L; Xu M; Millar S; Andl T · 2026 · Cancer research communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Cancer-associated fibroblasts (CAFs) display remarkable plasticity, enabling them to adapt to therapeutic and mechanical stress within the tumor microenvironment (TME). Here, we identify a shared mechanotransduction pathway by which BRAF…
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Metadata source: Europe PMC · DOI 10.1158/2767-9764.crc-25-0682