Causal Link Between Obstructive Uropathy, Estradiol, and Risk of Breast Cancer: Insights From Observational Evidence and Genetic Association Analyses
Hailu Wang; Yingying Dai; Wenhai Pan; Kaiyuan Mao; Zhiyi Zhang; Yan Zhang; Yifan Chen; Yiyin Zhang · 2026 · Medicine Advances
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT Background Estradiol, the key endogenous estrogen, reduces the risk of urinary obstruction by smooth muscle relaxation but also increases susceptibility to breast cancer (BC). However, whether estradiol serves as a mechanistic mediator linking urinary tract obstruction and BC remains unclear. This study aimed to determine if there is an association between urinary tract obstruction and the risk of BC and to assess the potential mediating role of systemic estradiol. Methods A case‐control study and survival analysis of Cox regression were conducted using clinical data from the United K
Abstract by Hailu Wang; Yingying Dai; Wenhai Pan; Kaiyuan Mao; Zhiyi Zhang; Yan Zhang; Yifan Chen; Yiyin Zhang, Medicine Advances (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1002/med4.70048