Renal fibrosis is induced by hyperactive Wnt/β-catenin pathway via microbial-mediated tryptophan metabolism-driven AhR signaling in rodents and humans
Limin Liu; Qing-Qing Yu; Yulu Zhang; Jing-Teng Zhou; Ying Jin; Chenhui Jiang; Shougang Zhuang; Jiali Wei · 2026 · Cellular and Molecular Life Sciences
WASTE classifies this as Abandoned Hypothesis · AI classification, approximate
A hypothesis was tested and not supported — a dead end worth knowing about before you pursue it.
Abstract (excerpt)
Renal fibrosis is a common pathological endpoint in progressive chronic kidney disease (CKD). Clinical evidence indicates that a decline in renal function is more closely associated with tubulointerstitial fibrosis (TIF) than with…
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Metadata source: OpenAlex · DOI 10.1007/s00018-026-06176-3