Negative / Null Result ReportOpen accessMedicine· cited by 108

FTO and MC4R Gene Variants Are Associated with Obesity in Polycystic Ovary Syndrome

Kathryn G. Ewens; Michelle R. Jones; Wendy Ankener; Douglas R. Stewart; Margrit Urbanek; Andrea Dunaif; Richard S. Legro; Angela K. Chua · 2011 · PLoS ONE

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in women. It is also associated with metabolic disturbances that place women at increased risk for obesity and type 2 diabetes. There is strong evidence for familial clustering of PCOS and a genetic predisposition. However, the gene(s) responsible for the PCOS phenotypes have not been elucidated. This two-phase family-based and case-control genetic study was designed to address the question of whether SNPs identified as susceptibility loci for obesity in genome-wide association studies (GWAS) are also associated w

Abstract by Kathryn G. Ewens; Michelle R. Jones; Wendy Ankener; Douglas R. Stewart; Margrit Urbanek; Andrea Dunaif; Richard S. Legro; Angela K. Chua, PLoS ONE (2011) — licensed CC BY 4.0.

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