Negative / Null Result ReportOpen accessMedicine

Genome-wide association study of vitamin D concentrations and bone mineral density in the African American-Diabetes Heart Study.

Nicholette D Palmer; Lingyi Lu; Thomas C Register; Leon Lenchik; J Jeffrey Carr; Pamela J Hicks; S Carrie Smith; Jianzhao Xu · 2021 · PLoS ONE

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Relative to European Americans, African Americans have lower 25-hydroxyvitamin D (25OHD) and vitamin D binding protein (VDBP) concentrations, higher 1,25-dihydroxyvitamin D (1,25(OH)2D3) concentrations and bone mineral density (BMD), and paradoxically reduced burdens of calcified atherosclerotic plaque (subclinical atherosclerosis). To identify genetic factors contributing to vitamin D and BMD measures, association analysis of >14M variants was conducted in a maximum of 697 African American-Diabetes Heart Study participants with type 2 diabetes (T2D). The most significant association signals w

Abstract by Nicholette D Palmer; Lingyi Lu; Thomas C Register; Leon Lenchik; J Jeffrey Carr; Pamela J Hicks; S Carrie Smith; Jianzhao Xu, PLoS ONE (2021) — licensed CC BY 4.0.

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