A single dorsal vagal complex circuit mediates the aversive and anorectic responses to GLP1R agonists
Warren T. Yacawych; Yi Wang; Guoxiang Zhou; Shad Hassan; Çağrı Bodur; Elisabeth Walters; John G. Santinga; Frederike Sass · 2026 · Journal of Clinical Investigation
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
GLP-1 receptor agonists (GLP1RAs) effectively reduce feeding to treat obesity, although nausea and other aversive side effects of these drugs can limit their use. Brainstem circuits that promote satiation and mediate the physiological control of body weight can be distinguished from those that cause aversion. It remains unclear whether brainstem Glp1r neurons contribute to the normal regulation of energy balance and whether GLP1RAs control appetite via circuits distinct from those that mediate aversive responses, however. Here, we silenced Glp1r neurons in the nucleus of the solitary tract or
Abstract by Warren T. Yacawych; Yi Wang; Guoxiang Zhou; Shad Hassan; Çağrı Bodur; Elisabeth Walters; John G. Santinga; Frederike Sass, Journal of Clinical Investigation (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1172/jci193743