IGFBP7 and left ventricular mass regression: a sub‐analysis of the EMPA‐HEART CardioLink‐6 randomized clinical trial
Pankaj Puar; Nikhil Mistry; Kim A. Connelly; Andrew T. Yan; Adrian Quan; Hwee Teoh; Yi Pan; Raj Verma · 2023 · ESC Heart Failure
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Aims Given recent suggestions that serum levels of insulin‐like growth factor‐binding protein 7 (IGFBP7) may identify patients who derive greater cardiorenal benefits from treatment with sodium‐glucose transport 2 inhibitors (SGLT2i), this exploratory sub‐analysis of the EMPA‐HEART CardioLink‐6 randomized controlled trial evaluated the association between serum levels of IGFBP7 and empagliflozin‐mediated left ventricular mass regression. Methods and results The EMPA‐HEART CardioLink‐6 trial used gold‐standard cardiac magnetic resonance imaging to detect change in left ventricular mass
Abstract by Pankaj Puar; Nikhil Mistry; Kim A. Connelly; Andrew T. Yan; Adrian Quan; Hwee Teoh; Yi Pan; Raj Verma, ESC Heart Failure (2023) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Rejuvenated Circulating Endothelial Progenitor Cells and Nitric Oxide in Premenopausal Women with Hyperhomocysteinemia
Negative / Null Result ReportMonocyte matrix metalloproteinase production in Type 2 diabetes and controls – a cross sectional study
Negative / Null Result ReportComparison short time discharge with long time discharge following uncomplicated percutaneous coronary intervention for Non-ST elevation myocardial infarction patients
Negative / Null Result ReportOral milrinone for management of refractory right ventricular failure in patients with left ventricular assist devices
Negative / Null Result ReportReciprocal ST segment changes in acute inferior myocardial infarction: Clinical, hemodynamic and angiographic implications
Negative / Null Result ReportThe effect of subchronic cigarette smoke exposure on oxidative stress parameters and endothelial nitric oxide synthase in a rat aorta
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.1002/ehf2.14335