Dissecting the effect of mitochondrial BCAT inhibition in methylmalonic acidemia.
Hemmingsen MG; Zhang GF; Ma Y; Marchuk H; Patel KR; Chen T; Li X; Chapman M · 2025 · JCI insight
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Methylmalonic acidemia (MMA) is a severe metabolic disorder affecting multiple organs because of a distal block in branched-chain amino acid (BCAA) catabolism. Standard of care is limited to protein restriction and supportive care during…
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Metadata source: Europe PMC · DOI 10.1172/jci.insight.187758