Cracking the Skin Barrier: Models and Methods Driving Dermal Drug Delivery
Francelle Bouwer; Marius Brits; Joe M. Viljoen · 2025 · Pharmaceutics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Dermal drug delivery is a promising alternate route of drug administration, offering localized therapeutic effects, reduced systemic effects, and improved patient compliance. However, the skin’s intricate configuration, especially the stratum corneum (SC), presents formidable barriers, restricting drug permeation. This review summarizes biological, synthetic, and methodological models employed to study dermal absorption and permeability. Ex vivo human skin is a reference point, but limited availability and ethical constraints necessitate reliance on animal models, including porcine, rodent, ra
Abstract by Francelle Bouwer; Marius Brits; Joe M. Viljoen, Pharmaceutics (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/pharmaceutics17121586