Efficacy and Safety of Denosumab versus Zoledronic Acid in the Treatment of Hypercalcemia in Primary Hyperparathyroidism: A Retrospective Comparative Study.
Liu Y; Liu L; Wang J; Jia H; Wang J; He Q; Liu M; Wang K · 2026 · Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Objective Nephrotoxicity of bisphosphonates limits their utility in the management of severe hypercalcemia among patients with primary hyperparathyroidism (PHPT) and impaired renal function. It remains unclear whether denosumab is an…
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Metadata source: Europe PMC · DOI 10.1016/j.eprac.2026.05.034