The effect of laser-assisted hatching on clinical outcomes of frozen-thawed embryo transfer at different embryo ages
Min-Min Ou; Bi-Yun Liao; Xing-Hong Chen; Lin-Lin Hu; Yu-Lan Lu; Hai-Mei Qin; Jun-Li Wang; Yu-Xia Wei · 2026 · European Journal of Obstetrics & Gynecology and Reproductive Biology: X
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Objective: To investigate the impact of laser-assisted hatching (LAH) on clinical outcomes in patients undergoing frozen-thawed embryo transfer (FET) cycles with embryos at different developmental stages. Methods: We conducted a retrospective analysis of 2208 patients who underwent vitrification-thawed FET at our reproductive center between October 2018 and June 2024, with some patients contributing multiple cycles. Patients were stratified by embryonic developmental stage into cleavage-stage FET (n = 793) and blastocyst-stage FET (n = 1415) groups. Each group was further subdivided based on p
Abstract by Min-Min Ou; Bi-Yun Liao; Xing-Hong Chen; Lin-Lin Hu; Yu-Lan Lu; Hai-Mei Qin; Jun-Li Wang; Yu-Xia Wei, European Journal of Obstetrics & Gynecology and Reproductive Biology: X (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.eurox.2026.100448