Negative / Null Result ReportOpen accessMedicine· cited by 77

Association of Bax Expression and Bcl2/Bax Ratio with Clinical and Molecular Prognostic Markers in Chronic Lymphocytic Leukemia

Ksenija Vučićević; Vladimir Jakovljević; Nataša Čolović; Nataša Tos̆ić; Tatjana Kostić; Irena Glumac; Sonja Pavlović; Teodora Karan-Djurašević · 2016 · Journal of Medical Biochemistry

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Summary Background: In chronic lymphocytic leukemia (CLL), in vivo apoptotic resistance of malignant B lymphocytes results, in part, from the intrinsic defects of their apoptotic machinery. These include genetic alterations and aberrant expression of many apoptosis regulators, among which the Bcl2 family members play a central role. Aim: The aim of this study was to investigate the association of pro-apoptotic Bax gene expression and Bcl2/Bax ratio with the clinical features of CLL patients as well as with molecular prognostic markers, namely the mutational status of rearranged immunoglobulin

Abstract by Ksenija Vučićević; Vladimir Jakovljević; Nataša Čolović; Nataša Tos̆ić; Tatjana Kostić; Irena Glumac; Sonja Pavlović; Teodora Karan-Djurašević, Journal of Medical Biochemistry (2016) — licensed CC BY 4.0.

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