Kawasaki disease and 13-valent pneumococcal conjugate vaccination among young children: A self-controlled risk interval and cohort study with null results
Meghan A. Baker; Bethany Baer; Martin Kulldorff; Lauren Zichittella; Rebecca Reindel; Sandra DeLuccia; Hana Lipowicz; Katherine E. Freitas · 2019 · PLoS Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Kawasaki disease is an acute vasculitis that primarily affects children younger than 5 years of age. Its etiology is unknown. The United States Vaccine Safety Datalink conducted postlicensure safety surveillance for 13-valent pneumococcal conjugate vaccine (PCV13), comparing the risk of Kawasaki disease within 28 days of PCV13 vaccination with the historical risk after 7-valent PCV (PCV7) vaccination and using chart-validation. A relative risk (RR) of 2.38 (95% CI 0.92-6.38) was found. Concurrently, the Food and Drug Administration (FDA) conducted a postlicensure safety review that
Abstract by Meghan A. Baker; Bethany Baer; Martin Kulldorff; Lauren Zichittella; Rebecca Reindel; Sandra DeLuccia; Hana Lipowicz; Katherine E. Freitas, PLoS Medicine (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pmed.1002844