Semaglutide slows epigenetic aging in a randomized trial of HIV-associated lipohypertrophy
Michael J. Corley; Varun B. Dwaraka; Alina P.S. Pang; Danielle E. Labbato; Ryan Smith; Allison Ross Eckard; Grace A. McComsey · 2026 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Glucagon-like peptide-1 (GLP-1) receptor agonists have attracted interest as gerotherapeutics, yet clinical-trial evidence for their effects on biological aging is lacking. We report a post hoc exploratory epigenetic age analysis of a 32-week, randomized, double-blind, placebo-controlled phase 2b trial (NCT04019197) of semaglutide in adults with human immunodeficiency virus (HIV)-associated lipohypertrophy (semaglutide n = 45; placebo n = 39). The parent trial's primary endpoint was change in visceral adipose tissue, with secondary cardiometabolic and body-composition endpoints; epigenetic agi
Abstract by Michael J. Corley; Varun B. Dwaraka; Alina P.S. Pang; Danielle E. Labbato; Ryan Smith; Allison Ross Eckard; Grace A. McComsey, Nature Communications (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-026-72861-3