Innovative polymer-based electrochemical platform for detecting ESAT-6 in human blood for pulmonary tuberculosis diagnosis
Xiu-An Ye; Shu-Hong Lin; Liang-Yu Chen; Jie-Ren Li; Hsiang-Wei Chiu; Sheng-Wei Pan; Jia-Yih Feng; Shyh-Chyang Luo · 2025 · Sensing and Bio-Sensing Research
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), necessitates early diagnosis for effective patient care. Despite advancements in TB diagnostics, there remains an urgent need to discover innovative non-sputum-based methods to detect Mtb-specific antigens for TB patient identification. We have developed a polymer-based electrochemical biosensor for detecting an Mtb-specific antigen, the 6-kDa early secreted antigenic target (ESAT-6), in blood. Using a gold electrode (Au), the biosensor is created by electropolymerizing poly(3,4-ethylene dioxythiophene) with carboxyl grou
Abstract by Xiu-An Ye; Shu-Hong Lin; Liang-Yu Chen; Jie-Ren Li; Hsiang-Wei Chiu; Sheng-Wei Pan; Jia-Yih Feng; Shyh-Chyang Luo, Sensing and Bio-Sensing Research (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.sbsr.2025.100816