Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift

Abstract

BACKGROUND: Animal model studies show that reductive stress is involved in cardiomyopathy and myopathy, but the exact physiological relevance remains unknown. In addition, the microRNAs miR-143 and miR-145 have been shown to be upregulated in cardiac diseases, but the underlying mechanisms associated with these regulators have yet to be explored. METHODS: We developed transgenic mouse lines expressing exogenous miR-143 and miR-145 under the control of the alpha-myosin heavy chain (αMHC) promoter/enhancer. RESULTS: The two transgenic lines showed dilated cardiomyopathy-like characteristics and

Abstract by Kota Ogawa; Akiko Noda; Jun Ueda; Takehiro Ogata; Rumiko Matsuyama; Yuji Nishizawa; Shanlou Qiao; Satoru Iwata, Cellular & Molecular Biology Letters (2020) — licensed CC BY 4.0.

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