NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients.
Marta Schirripa; Wu Zhang; Dongyun Yang; Shu Cao; Satoshi Okazaki; Fotios Loupakis; Martin D Berger; Yan Ning · 2018 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND:Macrophages play a crucial role in the interaction between tumor and immune system, and iNOS is known as a surrogate marker of M1 macrophages activation. The goal of the study was to investigate the role of iNOS polymorphisms as prognostic marker in mCRC patients. MATERIALS AND METHODS:Functional significant polymorphisms in the promoter of INOS gene were analyzed by PCR-based and direct DNA sequencing in 4 cohorts of patients receiving bevacizumab based first-line chemotherapy: two evaluation cohorts (TRIBE ARM A and ARM B) and two validation cohorts (FIRE 3 arm A and MOMA). The re
Abstract by Marta Schirripa; Wu Zhang; Dongyun Yang; Shu Cao; Satoshi Okazaki; Fotios Loupakis; Martin D Berger; Yan Ning, PLoS ONE (2018) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pone.0193640