HuR drives lung fibroblast differentiation but not metabolic reprogramming in response to TGF-β and hypoxia
Joshua Trivlidis; Noof Aloufi; Fatmah Al-Habeeb; Parameswaran Nair; Ilan Azuelos; David H. Eidelman; Carolyn J. Baglole · 2021 · Respiratory Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Pulmonary fibrosis is thought to be driven by recurrent alveolar epithelial injury which leads to the differentiation of fibroblasts into α-smooth muscle actin (α-SMA)-expressing myofibroblasts and subsequent deposition of extracellular matrix (ECM). Transforming growth factor beta-1 (TGF-β1) plays a key role in fibroblast differentiation, which we have recently shown involves human antigen R (HuR). HuR is an RNA binding protein that also increases the translation of hypoxia inducible factor (HIF-1α) mRNA, a transcription factor critical for inducing a metabolic shift from
Abstract by Joshua Trivlidis; Noof Aloufi; Fatmah Al-Habeeb; Parameswaran Nair; Ilan Azuelos; David H. Eidelman; Carolyn J. Baglole, Respiratory Research (2021) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Predictors of procedural success and improvement of left ventricular ejection fraction after successful recanalization of coronary chronic total occlusion (CTO)
Negative / Null Result ReportUse of transcutaneous electrical acupoint stimulation in pulmonary surgery for patients with tuberculosis
Negative / Null Result ReportBreathlessness worsened by haemodialysis
Negative / Null Result ReportAssociations between serum 25(OH)D concentrations and prevalent asthma among children living in communities with differing levels of urbanization: a cross-sectional study
Negative / Null Result ReportSystemic inflammatory response to inhaled endotoxin does not correlate with airway response
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.1186/s12931-021-01916-4