RNA Interference Therapy With ARC‐520 Results in Prolonged Hepatitis B Surface Antigen Response in Patients With Chronic Hepatitis B Infection
Man‐Fung Yuen; Ingolf Schiefke; Jung‐Hwan Yoon; Sang Hoon Ahn; Jeong Heo; Ju Hyun Kim; Henry Lik‐Yuen Chan; Ki Tae Yoon · 2019 · Hepatology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND AND AIMS: ARC-520, the first an RNA interference (RNAi) therapeutic, was designed to reduce all RNA transcripts derived from covalently closed circular DNA, leading to a reduction in viral antigens and hepatitis B virus (HBV)…
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Metadata source: OpenAlex · DOI 10.1002/hep.31008