Amyloid-beta-targeting monoclonal antibodies for people with mild cognitive impairment or mild dementia due to Alzheimer’s disease
Francesco Nonino; Silvia Minozzi; L. Sambati; Cinzia Del Giovane; Elisa Baldin; Maria Chiara Bassi; Claudia De Santis; Marien Gonzalez-Lorenzo · 2026 · Cochrane Database of Systematic Reviews
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
RATIONALE: Alzheimer's disease is a neurodegenerative disorder and the most common cause of dementia. Aggregated amyloid-beta protein deposits are implicated in its pathogenesis. Amyloid-beta-targeting monoclonal antibodies (sometimes represented as Aβ-mAbs) are potentially disease-modifying for Alzheimer's disease: through the clearance of amyloid in the brain, they may slow cognitive and functional decline. OBJECTIVES: To assess the clinical benefits and harms of amyloid-beta-targeting monoclonal antibodies aducanumab, bapineuzumab, crenezumab, donanemab, gantenerumab, lecanemab, ponezumab,
Abstract by Francesco Nonino; Silvia Minozzi; L. Sambati; Cinzia Del Giovane; Elisa Baldin; Maria Chiara Bassi; Claudia De Santis; Marien Gonzalez-Lorenzo, Cochrane Database of Systematic Reviews (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1002/14651858.cd016297