Longitudinal Blood-Based Biomarkers and Clinical Progression in Subjective Cognitive Decline
Calvin Trieu; Argonde C. van Harten; Mardou S. S. A. van Leeuwenstijn; Lisa‐Marie Schlüter; Lynn Boonkamp; Azzam Aladdin; Sietske A.M. Sikkes; Elsmarieke van de Giessen · 2025 · JAMA Network Open
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Importance: Blood-based biomarkers identify Alzheimer disease and hold promise for monitoring disease progression, even in the preclinical disease stages. Objective: To investigate longitudinal trajectories of blood-based biomarkers and association with cognitive decline and risk of progression in individuals with subjective cognitive decline (SCD). Design, Setting, and Participants: This prospective cohort study (Subjective Cognitive Impairment Cohort) of individuals with SCD evaluated at a memory clinic underwent biennial biomarker collection and annual cognitive assessment and diagnostic ev
Abstract by Calvin Trieu; Argonde C. van Harten; Mardou S. S. A. van Leeuwenstijn; Lisa‐Marie Schlüter; Lynn Boonkamp; Azzam Aladdin; Sietske A.M. Sikkes; Elsmarieke van de Giessen, JAMA Network Open (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1001/jamanetworkopen.2025.45862