Negative / Null Result ReportOpen accessMedicine· cited by 328

No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over

Jane Warwick; Emanuela Falaschetti; Kenneth Rockwood; Arnold Mitnitski; Lutgarde Thijs; Nigel Beckett; Christopher J. Bulpitt; Ruth Peters · 2015 · BMC Medicine

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

BACKGROUND: Treatment for hypertension with antihypertensive medication has been shown to reduce stroke, cardiovascular events, and mortality in older adults, but there is concern that such treatment may not be appropriate in frailer older adults. To investigate whether there is an interaction between effect of treatment for hypertension and frailty in older adults, we calculated the frailty index (FI) for all available participants from the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 an

Abstract by Jane Warwick; Emanuela Falaschetti; Kenneth Rockwood; Arnold Mitnitski; Lutgarde Thijs; Nigel Beckett; Christopher J. Bulpitt; Ruth Peters, BMC Medicine (2015) — licensed CC BY 4.0.

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