Efficacy assessment of a novel endolysin PlyAZ3aT for the treatment of ceftriaxone-resistant pneumococcal meningitis in an infant rat model.
Luca G Valente; Ngoc Dung Le; Melissa Pitton; Gabriele Chiffi; Denis Grandgirard; Stephan M Jakob; David R Cameron; Grégory Resch · 2022 · PLoS ONE
WASTE classifies this as Failed Experiment Report · AI classification, approximate
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Abstract
Background Treatment failure in pneumococcal meningitis due to antibiotic resistance is an increasing clinical challenge and alternatives to antibiotics warrant investigation. Phage-derived endolysins efficiently kill gram-positive bacteria including multi-drug resistant strains, making them attractive therapeutic candidates. The current study assessed the therapeutic potential of the novel endolysin PlyAZ3aT in an infant rat model of ceftriaxone-resistant pneumococcal meningitis. Methods Efficacy of PlyAZ3aT was assessed in a randomized, blinded and controlled experimental study in infant Wis
Abstract by Luca G Valente; Ngoc Dung Le; Melissa Pitton; Gabriele Chiffi; Denis Grandgirard; Stephan M Jakob; David R Cameron; Grégory Resch, PLoS ONE (2022) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pone.0266928