Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
Rositsa Mihaylova; Viktoria Elincheva; Rumyana Simeonova; Georgi Momekov · 2026 · Molecules
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
species, and other medicinal plants, exemplifies the therapeutic potential and translational complexity of the broader anthraquinone scaffold. Anthraquinone derivatives have demonstrated antiproliferative, anti-inflammatory, metabolic, cardiovascular, antifibrotic, and immunomodulatory effects, consistently reported across diverse preclinical models, targeting pathways such as NF-κB, PI3K/AKT, MAPKs, AMPK, PPARs, NLRP3, and ferroptosis-related axes. Despite strong preclinical efficacy, clinical development has been limited by unfavorable absorption, distribution, metabolism, and excretion (ADM
Abstract by Rositsa Mihaylova; Viktoria Elincheva; Rumyana Simeonova; Georgi Momekov, Molecules (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/molecules31050833