Association between phthalate exposure and accelerated bone maturation in Chinese girls with early puberty onset: a propensity score-matched case–control analysis
Shurong Huang; Zhe Su; Huiping Su; Yanhua Jiao; Qiru Su; Yao Yao; Li Zhou; Xiuxin Zheng · 2022 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Estrogen can promote the acceleration of bone maturation and phthalate esters (PAEs) have estrogen-mimicking effects. We investigated whether PAEs are associated with the acceleration of bone age (BA) in girls with early onset of puberty (EOP). This case–control study enrolled 254 girls with EOP from the Endocrinology Department at Shenzhen Children’s Hospital between December 2018 and August 2019. Ultra-performance liquid chromatography and tandem mass spectrometry were used to analyze the 10 metabolites of PAEs (mPAEs) in urine samples. BA was measured using an artificial intelligen
Abstract by Shurong Huang; Zhe Su; Huiping Su; Yanhua Jiao; Qiru Su; Yao Yao; Li Zhou; Xiuxin Zheng, Scientific Reports (2022) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1038/s41598-022-19470-4