Integration of plasma eMTBR-tau243 and p-tau217 in the diagnosis and stratification of Alzheimer's disease: a prospective cohort study
Niklas Mattsson-Carlgren; Sebastian Palmqvist; Kanta Horie; Nicolas Barthélemy; Gemma Salvadó; Alexa Pichet Binette; Pontus Tideman; John C Morris · 2026 · The Lancet Neurology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Alzheimer's disease pathology can be accurately identified with blood biomarkers (core 1 biomarkers), including plasma p-tau217 tests. Biomarkers that change longitudinally after diagnosis (core 2 biomarkers) can increase confidence that Alzheimer's disease pathology is contributing to cognitive symptoms. Plasma eMTBR-tau243 reflects tau tangle pathology and is a promising core 2 biomarker. We aimed to examine whether, among patients positive for plasma p-tau217, plasma eMTBR-tau243 improves classification of established Alzheimer's disease and predicts cognitive decline and tau ta
Abstract by Niklas Mattsson-Carlgren; Sebastian Palmqvist; Kanta Horie; Nicolas Barthélemy; Gemma Salvadó; Alexa Pichet Binette; Pontus Tideman; John C Morris, The Lancet Neurology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/s1474-4422(26)00029-3