Expression of interferon-stimulated genes, but not polymorphisms in the interferon α/β receptor 2 gene, is associated with coronavirus disease 2019 mortality
Berliana Hamidah; Cennikon Pakpahan; Laksmi Wulandari; Damayanti Tinduh; Tri Wibawa; Cita Rosita Sigit Prakoeswa; Delvac Oceandy · 2024 · Heliyon
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Excessive inflammatory response is a hallmark of severe COVID-19. This study investigated the associations between interferon-stimulated genes (ISGs) expression, genetic variation in the interferon α/β receptor 2 (IFNAR2) gene, and COVID-19 mortality.We investigated 67 patients with moderate-to-severe COVID-19. Of them, 22 patients (32.8 %) died because of COVID-19. We examined the expression of ISGs in total RNA of peripheral whole blood. We observed a significant increase in the expression of all ISGs examined in non-surviving patients, indicating a heightened interferon type I signaling act
Abstract by Berliana Hamidah; Cennikon Pakpahan; Laksmi Wulandari; Damayanti Tinduh; Tri Wibawa; Cita Rosita Sigit Prakoeswa; Delvac Oceandy, Heliyon (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.heliyon.2024.e39002