Advances and challenges in immunotherapy in head and neck cancer
Hazem Aboaid; Taimur Khalid; Abbas Hussain; Yin Mon Myat; Rishi Kumar Nanda; Ramaditya Srinivasmurthy; Kevin Nguyen; Daniel T. Jones · 2025 · Frontiers in Immunology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Head and neck squamous cell carcinoma (HNSCC) remains a challenging malignancy with suboptimal survival outcomes despite advances in surgery, radiotherapy, and chemotherapy. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1), has transformed treatment paradigms, yet its full potential in HNSCC is still being explored. This review evaluates the current landscape of immunotherapy in both locally advanced (LA) and recurrent/metastatic (R/M) HNSCC, discussing key clinical trials, emerging biomarker
Abstract by Hazem Aboaid; Taimur Khalid; Abbas Hussain; Yin Mon Myat; Rishi Kumar Nanda; Ramaditya Srinivasmurthy; Kevin Nguyen; Daniel T. Jones, Frontiers in Immunology (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fimmu.2025.1596583