FMR1, circadian genes and depression: suggestive associations or false discovery?
Daniel F. Kripke; Caroline M. Nievergelt; Gregory J. Tranah; Sarah S. Murray; Katharine M. Rex; Alexandra P. Grizas; Elizabeth K. Hahn; Heon‐Jeong Lee · 2013 · Journal of Circadian Rhythms
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: There are several indications that malfunctions of the circadian clock contribute to depression. To search for particular circadian gene polymorphisms associated with depression, diverse polymorphisms were genotyped in two samples covering a range of depressed volunteers and participants with normal mood. METHODS: Depression mood self-ratings and DNA were collected independently from a sample of patients presenting to a sleep disorders center (1086 of European origin) and from a separate sample consisting of 399 participants claiming delayed sleep phase symptoms and 406 partly-matc
Abstract by Daniel F. Kripke; Caroline M. Nievergelt; Gregory J. Tranah; Sarah S. Murray; Katharine M. Rex; Alexandra P. Grizas; Elizabeth K. Hahn; Heon‐Jeong Lee, Journal of Circadian Rhythms (2013) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/1740-3391-11-3