Diffusion tensor image analysis along the perivascular space (DTI-ALPS): redefining its interpretation and role
Toshiaki Taoka; Rintaro Ito; Rei Nakamichi; Toshiki Nakane; Shinji Naganawa · 2026 · Japanese Journal of Radiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Diffusion tensor image analysis along the perivascular space (DTI-ALPS) was originally developed and defined as a noninvasive diffusion MRI method intended to evaluate glymphatic function and is now widely used in neuroimaging research. However, accumulating evidence suggests that the biological meaning of the ALPS index is more complex than initially assumed as a simple marker of glymphatic function. The ALPS index does not directly measure whole-brain fluid transport but rather reflects localized directional diffusivity based on the Brownian motion of water molecules. Its value is strongly i
Abstract by Toshiaki Taoka; Rintaro Ito; Rei Nakamichi; Toshiki Nakane; Shinji Naganawa, Japanese Journal of Radiology (2026) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Reproducible brain-wide association studies require thousands of individuals
Negative / Null Result ReportDaily Left Prefrontal Transcranial Magnetic Stimulation Therapy for Major Depressive Disorder
Negative / Null Result ReportEarly Brain Overgrowth in Autism Associated With an Increase in Cortical Surface Area Before Age 2 Years
Negative / Null Result ReportObjective evaluation of anosmia and ageusia in COVID‐19 patients: Single‐center experience on 72 cases
Negative / Null Result ReportPolarity and timing-dependent effects of transcranial direct current stimulation in explicit motor learning
Negative / Null Result ReportThe feedback-related negativity (FRN) revisited: New insights into the localization, meaning and network organization
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: OpenAlex · DOI 10.1007/s11604-026-02035-0