Clinical characteristics and frequency of TLR4 polymorphisms in Brazilian patients with ankylosing spondylitis
Natalia Pereira Machado; Eliana Nogueira; Karen Oseki; Pâmela Carolina Cruz Ebbing; Clarice Silvia Taemi Origassa; Tatiane Mohovic; Niels Olsen Saraiva Câmara; Marcelo de Medeiros Pinheiro · Revista Brasileira de Reumatologia
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Abstract
ABSTRACT Objectives: Innate immunity is involved in the physiopathology of ankylosing spondylitis (AS), with the participation of Gram-negative bacteria, modulation of human leukocyte antigen (HLA) B27 and the involvement of pattern recognition receptors, such as Toll-like receptors (TLRs). The aim of this study was to investigate the clinical characteristics and frequency of TLR4 polymorphisms (Asp299Gly and Thr 399Ile) in a cohort of Brazilian patients with AS. Methods: A cross-sectional study was carried out involving 200 patients with a diagnosis of AS and a healthy control group of 200 in
Abstract by Natalia Pereira Machado; Eliana Nogueira; Karen Oseki; Pâmela Carolina Cruz Ebbing; Clarice Silvia Taemi Origassa; Tatiane Mohovic; Niels Olsen Saraiva Câmara; Marcelo de Medeiros Pinheiro, Revista Brasileira de Reumatologia — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.rbre.2016.07.004