Multicenter Prospective Validation of an Updated Proprietary Sepsis Prediction Model
Andrew Wong; Danielle Currey; Megan Schwinne; Brenna Park-Egan; Sean R. Meyer; Andrew A. Gutting; Jie Cao; Sharaf Khan · 2026 · JAMA Network Open
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Importance: The Epic Sepsis Model version 2 (ESM v2) is a widely implemented proprietary sepsis prediction model, but no multicenter, external validation of its performance has been reported to guide adoption and use. Objective: To conduct a multicenter validation of the ESM v2 to compare performance against the original ESM v1, outline differences across heterogenous clinical sites, and compare model performance against clinician recognition of sepsis. Design, Setting, and Participants: This prognostic study included adult inpatient encounters at 4 large US health systems between August 31, 2
Abstract by Andrew Wong; Danielle Currey; Megan Schwinne; Brenna Park-Egan; Sean R. Meyer; Andrew A. Gutting; Jie Cao; Sharaf Khan, JAMA Network Open (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1001/jamanetworkopen.2026.0181