Timing-Dependent Cleavage of Interleukin-1 Receptor Antagonist by Alteplase Impairs Neuroprotection in Ischemic Stroke.
Mosneag IE; Rubio M; Lemarchand E; Ohene Y; Dickie BR; Jones R; Coutts G; Ritchie E · 2026 · Stroke
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background Inflammation contributes significantly to neuronal damage in ischemic stroke, with IL (interleukin)-1 being a key mediator. IL-1Ra (IL-1 receptor antagonist) inhibits IL-1 signaling, successfully reducing inflammation in…
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Metadata source: Europe PMC · DOI 10.1161/strokeaha.125.054941