Negative / Null Result ReportOpen accessMedicine· cited by 9

Immunophenotypic Profile of Adult Glioblastoma IDH-Wildtype Microenvironment: A Cohort Study

Sofia Asioli; Lidia Gatto; Uri Vardy; Claudio Agostinelli; Vincenzo Di Nunno; Simona Righi; Alicia Tosoni; Francesca Ambrosi · 2024 · Cancers

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Background: Glioblastoma IDH-wildtype (GBM IDH-wt) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping its tumor microenvironment (TME) regulate tumor progression and treatment response. The aim of this study was to characterize the main immunosuppressive elements of the GBM IDH-wt TME. Methods: Immunohistochemistry for CD3, CD4, CD8, CD163, programmed death ligand 1 (PD-L1) and programmed death 1 (PD1) was performed on surgical tumor specimens from patients diagnosed with GBM IDH-wt, according to the CNS WHO 202

Abstract by Sofia Asioli; Lidia Gatto; Uri Vardy; Claudio Agostinelli; Vincenzo Di Nunno; Simona Righi; Alicia Tosoni; Francesca Ambrosi, Cancers (2024) — licensed CC BY 4.0.

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