Negative / Null Result ReportOpen accessMedicine· cited by 12

Central adiposity indices and inflammatory markers mediate the association between life’s crucial 9 and periodontitis in US adults

Jia-Jie Guo; Qi-Qi Hang; Ting Xu; Wang Liang; Jia-Kun Gao; Hanlin Ou; Fu-Zhen Jiang; Xueshan Qiu · 2025 · Lipids in Health and Disease

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

BACKGROUND: Periodontitis, a chronic inflammatory disease, is closely linked to cardiovascular health. While Life's Essential 8 (LE8) evaluates cardiovascular metrics, recent recommendations suggest incorporating psychological health (PHQ-9) to form Life's Crucial 9 (LC9). However, evidence regarding the utility of LC9 in periodontal disease remains limited. METHODS: We analyzed data from 7,674 adults in the 2009-2014 NHANES cycles. LC9 scores were calculated by integrating LE8 and PHQ-9 metrics, then categorized into quartiles. The association between LC9 and periodontitis was examined using

Abstract by Jia-Jie Guo; Qi-Qi Hang; Ting Xu; Wang Liang; Jia-Kun Gao; Hanlin Ou; Fu-Zhen Jiang; Xueshan Qiu, Lipids in Health and Disease (2025) — licensed CC BY 4.0.

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