Loss of the ER-cargo protein CLN8 increases severity of acute pancreatitis and upregulates ER-stress and ER-phagy.
Zierke L; Gischke M; Sendler M; Weiss FU; Ribback S; Skowronek D; Rath M; Völzke H · 2026 · Molecular biomedicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Acute pancreatitis is caused by a premature activation of digestive proteases. One hypothesis is based on the proteolytic activation of the serine protease trypsinogen by the lysosomal enzyme cathepsin B (CTSB) after co-localization in the…
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Metadata source: Europe PMC · DOI 10.1186/s43556-026-00479-4