A Phase 2a Study of the Early Bactericidal Activity of Rifampicin in Combination With Meropenem Plus Amoxicillin/Clavulanate Among Adults With Rifampicin-Resistant Pulmonary Tuberculosis.
de Jager V; Mockeliunas L; You H; Simonsson USH; Collings T; Upton CM; Bezuidenhout JA; Gupte N · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background In vitro, meropenem is shown to restore the activity of rifampicin in rifampicin-resistant Mycobacterium tuberculosis strains. This phase 2a trial aimed to determine if addition of rifampicin increases the early bactericidal…
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Metadata source: Europe PMC · DOI 10.1093/cid/ciaf276