Mitochondrial Health Through Nicotinamide Riboside and Berberine: Shared Pathways and Therapeutic Potential
F Visalli; Matteo Capobianco; F. Cappellani; Lorenzo Rapisarda; Alfonso Spinello; Alessandro Avitabile; Ludovica Cannizzaro; Caterina Gagliano · 2026 · International Journal of Molecular Sciences
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Abstract
Mitochondrial dysfunction represents a central hallmark of aging and a broad spectrum of chronic diseases, ranging from metabolic to neurodegenerative and ocular disorders. Nicotinamide riboside (NR), a vitamin B3 derivative and efficient precursor of NAD+ (nicotinamide adenine dinucleotide), and berberine (BBR), an isoquinoline alkaloid widely investigated in metabolic regulation, have independently emerged as promising mitochondrial modulators. NR enhances cellular NAD+ pools, thereby activating sirtuin-dependent pathways, stimulating PGC-1α–mediated mitochondrial biogenesis, and triggering
Abstract by F Visalli; Matteo Capobianco; F. Cappellani; Lorenzo Rapisarda; Alfonso Spinello; Alessandro Avitabile; Ludovica Cannizzaro; Caterina Gagliano, International Journal of Molecular Sciences (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/ijms27010485