Systemic blockade of dopamine D2-like receptors increases high-voltage spindles in the globus pallidus and motor cortex of freely moving rats.
Chen Yang; Shun-Nan Ge; Jia-Rui Zhang; Lei Chen; Zhi-Qiang Yan; Li-Jun Heng; Tian-Zhi Zhao; Wei-Xin Li · 2013 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
High-voltage spindles (HVSs) have been reported to appear spontaneously and widely in the cortical-basal ganglia networks of rats. Our previous study showed that dopamine depletion can significantly increase the power and coherence of HVSs in the globus pallidus (GP) and motor cortex of freely moving rats. However, it is unclear whether dopamine regulates HVS activity by acting on dopamine D₁-like receptors or D₂-like receptors. We employed local-field potential and electrocorticogram methods to simultaneously record the oscillatory activities in the GP and primary motor cortex (M1) in freely
Abstract by Chen Yang; Shun-Nan Ge; Jia-Rui Zhang; Lei Chen; Zhi-Qiang Yan; Li-Jun Heng; Tian-Zhi Zhao; Wei-Xin Li, PLoS ONE (2013) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pone.0064637