Negative / Null Result ReportOpen accessMedicine· cited by 25

Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury

Marta Celorrio; Kirill Shumilov; Camryn Payne; Sangeetha Vadivelu; Stuart H. Friess · 2022 · Acta Neuropathologica Communications

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

The finding, in one line

“Clinical trials of therapeutics for traumatic brain injury (TBI) demonstrating preclinical efficacy for TBI have failed to replicate these results in humans, in part due to the absence of clinically feasible therapeutic windows for administration.”

Abstract

Clinical trials of therapeutics for traumatic brain injury (TBI) demonstrating preclinical efficacy for TBI have failed to replicate these results in humans, in part due to the absence of clinically feasible therapeutic windows for administration. Minocycline, an inhibitor of microglial activation, has been shown to be neuroprotective when administered early after experimental TBI but detrimental when administered chronically to human TBI survivors. Rather than focusing on the rescue of primary injury with early administration of therapeutics which may not be clinically feasible, we hypothesiz

Abstract by Marta Celorrio; Kirill Shumilov; Camryn Payne; Sangeetha Vadivelu; Stuart H. Friess, Acta Neuropathologica Communications (2022) — licensed CC BY 4.0.

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