Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women
Mahdiyeh Harati-Sadegh; Leila Kohan; Batool Teimoori; Mehrnaz Mehrabani; Saeedeh Salimi · 2019 · Journal of Biomedical Science
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Preeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in the pathophysiology of PE, although its precise pathogenic mechanisms are not well established. In this study, we aimed to identify the association between maternal TP53-rs1042522, P21-rs1801270, and P21-rs1059234 polymorphisms and PE. In addition, we examined the effects of promoter methylation and TP53 and P21 polymorphisms on placental mRNA expression in PE women. Methods The blood of 226 PE women and 228 normotensive pregnant women wa
Abstract by Mahdiyeh Harati-Sadegh; Leila Kohan; Batool Teimoori; Mehrnaz Mehrabani; Saeedeh Salimi, Journal of Biomedical Science (2019) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s12929-019-0586-x