Osteoarthritis: molecular pathogenesis and potential therapeutic options
Yi Zhang; Yanqi Han; Ying Sun; Longhui Hao; Yue Gao; Jun Ye; Hongliang Wang; Tiantai Zhang · 2026 · Signal Transduction and Targeted Therapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Osteoarthritis (OA) is a debilitating joint disorder that causes chronic pain, inflammation, and detrimental bone alterations. Despite significant advances in understanding OA pathogenesis, current therapeutic strategies remain inadequate in halting disease progression or providing effective pain relief, highlighting unmet clinical needs. Recent insights into OA nociceptive pathways, inflammatory mediators, and organelle dysfunction have revealed promising therapeutic targets. Specifically, OA progression is driven by mitochondrial dysfunction (marked by accumulated damaged mitochondria with e
Abstract by Yi Zhang; Yanqi Han; Ying Sun; Longhui Hao; Yue Gao; Jun Ye; Hongliang Wang; Tiantai Zhang, Signal Transduction and Targeted Therapy (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41392-025-02556-6