Ferroptosis in cardiovascular diseases: molecular mechanisms and a novel therapeutic target
Suli Yu; Zhen Pang; Hong Fang; Chi Liu · 2026 · Molecular Biomedicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Ferroptosis, a regulated cell death modality driven by iron accumulation and lipid peroxidation, has emerged as a pivotal pathophysiological mechanism across a broad spectrum of cardiovascular diseases (CVDs), which remain the leading cause of global mortality. Although robust preclinical evidence indicates that modulation of ferroptosis attenuates myocardial and vascular injury, clinical translation is constrained by incomplete understanding of context-specific roles, the paucity of validated biomarkers, and the absence of targeted therapeutics with acceptable safety profiles. In this Review,
Abstract by Suli Yu; Zhen Pang; Hong Fang; Chi Liu, Molecular Biomedicine (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s43556-026-00420-9