Subthalamic deep brain stimulation in Parkinson׳s disease has no significant effect on perceptual timing in the hundreds of milliseconds range
Thomas Cope; Manon Grube; Arnab Mandal; Freya E. Cooper; Una Brechany; David J. Burn; Timothy D. Griffiths · 2014 · Neuropsychologia
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Bilateral, high-frequency stimulation of the basal ganglia (STN-DBS) is in widespread use for the treatment of the motor symptoms of Parkinson׳s disease (PD). We present here the first psychophysical investigation of the effect of STN-DBS upon perceptual timing in the hundreds of milliseconds range, with both duration-based (absolute) and beat-based (relative) tasks; 13 patients with PD were assessed with their STN-DBS 'on', 'off', and then 'on' again. Paired parametric analyses revealed no statistically significant differences for any task according to DBS status. We demonstrate, from the exa
Abstract by Thomas Cope; Manon Grube; Arnab Mandal; Freya E. Cooper; Una Brechany; David J. Burn; Timothy D. Griffiths, Neuropsychologia (2014) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Reproducible brain-wide association studies require thousands of individuals
Negative / Null Result ReportDaily Left Prefrontal Transcranial Magnetic Stimulation Therapy for Major Depressive Disorder
Negative / Null Result ReportEarly Brain Overgrowth in Autism Associated With an Increase in Cortical Surface Area Before Age 2 Years
Negative / Null Result ReportObjective evaluation of anosmia and ageusia in COVID‐19 patients: Single‐center experience on 72 cases
Negative / Null Result ReportPolarity and timing-dependent effects of transcranial direct current stimulation in explicit motor learning
Negative / Null Result ReportThe feedback-related negativity (FRN) revisited: New insights into the localization, meaning and network organization
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: OpenAlex · DOI 10.1016/j.neuropsychologia.2014.02.021