Interferon-based agents for current and future viral respiratory infections: A scoping literature review of human studies
Aldina Mešić; Emahlea Jackson; Mathias Lalika; David M. Koelle; Rena C. Patel · 2022 · PLOS Global Public Health
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The interferon (IFN) system is a potent line of defense against viral infections. IFN-based agents already tested may be of use in COVID-19 or future viral respiratory outbreaks. Here we review the comparative efficacy, safety/tolerability, and future potential of IFN-based therapeutics. We reviewed human studies in which IFN or IFN pathway-interacting agents were used for viral respiratory infections. We identified 977 articles, of which 194 were included for full-text review. Of these, we deemed 35 articles to be relevant. The use of IFN-based agents for pre-exposure prophylaxis (n = 19) and
Abstract by Aldina Mešić; Emahlea Jackson; Mathias Lalika; David M. Koelle; Rena C. Patel, PLOS Global Public Health (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pgph.0000231